CAR-T疗法诞生以来，安全性一直是悬在头上的达摩克利斯之剑。CRS、ICANS以及长期安全信号，是无法逃避的话题。日前，FDA的几位高管在Annals of Interal Medicine上发表的一篇文章很好地阐述了他们的立场：将以灵活的监管方法支持这些新型细胞疗法的开发。
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The financial infrastructure of that commitment is already in place. The 10 largest AI companies are on track to issue more than $120 billion in bonds—a record high that many are drawing parallels to the debt Big Tech took on during the dotcom boom of the late 1990s. Unlike that era, when the Y2K bubble’s collapse was largely absorbed by equity investors, today’s AI buildout is being financed with debt, meaning a market correction would ripple well beyond stock portfolios.
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