The 80286 introduced "Protected Mode" in 1982. It was not popular. The mode was difficult to use, lacked paging, and offered no way to return to real mode without a hardware reset. The 80386, arriving three years later, made protection usable -- adding paging, a flat 32-bit address space, per-page User/Supervisor control, and Virtual 8086 mode so that DOS programs could run inside a protected multitasking system. These features made possible Windows 3.0, OS/2, and early Linux.
Nature, Published online: 25 February 2026; doi:10.1038/d41586-026-00132-8
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Mice learning a neurofeedback brain–computer interface task show neuron-specific teaching signals in cortical dendrites, consistent with a vectorized solution for credit assignment in the brain.
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